Sultana Yasmin, Maurya D P, Iqbal Z, Aqil M
Department of Pharmaceutics, Hamdard University, New Delhi, India.
Drugs Today (Barc). 2011 Jun;47(6):441-55. doi: 10.1358/dot.2011.47.6.1549023.
Our knowledge in the field of ocular drug delivery is rapidly expanding. An increase in the understanding of ocular drug absorption and disposition vis-à-vis developments in nanotechnology has led to the emergence of many of the nanotechnology-based ocular drug delivery systems including nanoparticles, microemulsions, liposomes, solid lipid nanoparticles, light-sensitive nanocarrier systems, etc. The need to develop effective treatments for posterior eye segment diseases is more important than surface delivery. Treatment of blinding diseases of the eye, such as proliferative retinopathy or macular degeneration, requires effective and safe delivery of drugs to posterior eye segment tissues, and recent advances in nanotechnology have demonstrated successful outcomes. Nanoscientists should focus their efforts on nano-ophthalmology. This review describes the current status and progress made so far, and the course that needs to be pursued in the future.
我们在眼部药物递送领域的知识正在迅速扩展。随着纳米技术的发展，人们对眼部药物吸收和处置的理解不断加深，这催生了许多基于纳米技术的眼部药物递送系统，包括纳米颗粒、微乳、脂质体、固体脂质纳米颗粒、光敏纳米载体系统等。开发针对眼后段疾病的有效治疗方法比表面给药更为重要。治疗眼部致盲疾病，如增殖性视网膜病变或黄斑变性，需要将药物有效且安全地递送至眼后段组织，而纳米技术的最新进展已取得了成功成果。纳米科学家应将精力集中在纳米眼科学上。本综述描述了目前的现状和迄今取得的进展，以及未来需要遵循的方向。
