Juillet Y, Aiach M, Fiessinger J N, Leclerc M, Housset E
Sem Hop. 1978;54(37-40):1126-9.
Antithrombin III concentration was studied in 86 patients with recurrent or extensive venous thrombosis. Two of them were found to have an hereditary antithrombin III deficiency. 25 patients receiving heparin therapy had low antithrombin III concentration. After stopping heparin treatment antithrombin rose to a normal level. Pathological antithrombin III modifications are recalled (synthesis decrease in liver diseases, intra vascular consumption during active venous thrombosis). Antithrombin III decreased activity induced by heparin treatment is pointed out.
对86例复发性或广泛性静脉血栓形成患者的抗凝血酶III浓度进行了研究。发现其中2例患有遗传性抗凝血酶III缺乏症。25例接受肝素治疗的患者抗凝血酶III浓度较低。停止肝素治疗后,抗凝血酶升高至正常水平。回顾了抗凝血酶III的病理性改变(肝脏疾病时合成减少,活动性静脉血栓形成时血管内消耗)。指出了肝素治疗引起的抗凝血酶III活性降低。