千里光属倍半萜内酯的体外抗疟活性。
In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia.
机构信息
Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, UBA, Junín 956, Buenos Aires 1113, Argentina.
出版信息
Evid Based Complement Alternat Med. 2011;2011:352938. doi: 10.1155/2011/352938. Epub 2011 May 25.
The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC(50)) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC(50) = 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)). Fifty percent cytotoxic concentration (CC(50)) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively.
已经评估了 Ambrosia tenuifolia 有机提取物及其分离的倍半萜内酯 psilostachyin 和 peruvin 对恶性疟原虫 F32 和 W2 株的体外抗疟活性。测定了这两种化合物对淋巴样细胞的细胞毒性，并计算了它们相应的选择性指数（SI）。peruvin 对 F32 株恶性疟原虫最为活跃，其 50%抑制浓度值（IC50）为 0.3μg/mL（1.1μM），而 psilostachyin 对两种菌株均有活性（IC50=0.6（2.1μM）和 1.8μg/mL（6.4μM））。psilostachyin 和 peruvin 的 50%细胞毒性浓度（CC50）值（48 小时）分别为 6.8μg/mL（24.3μM）和 10.0μg/mL（37.9μM）。
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