一种具有角甲基的手性六氢薁骨架的新环扩张。

A new ring expansion for a chiral hexahydroazulene skeleton possessing an angular methyl group.

机构信息

Laboratory of Organic Chemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.

出版信息

J Org Chem. 2011 Aug 19;76(16):6942-5. doi: 10.1021/jo201153h. Epub 2011 Jul 13.

DOI:10.1021/jo201153h

PMID:21721521

Abstract

A new synthetic route for a pseudoguaiane ring system is described. The synthesis features an Ireland-Claisen rearrangement for constructing the trans-fused ring system, followed by a new ring expansion to yield a bicyclo[5.3.0]decane ring system possessing an angular methyl group.

摘要

描述了一种伪瓜环烷体系的新合成路线。该合成方法的特点是采用爱尔兰-克莱森重排构建反式稠合环系，然后进行新的环扩张，得到具有角甲基的双环[5.3.0]癸烷环系。