Zárate Mariela S, Giannico Marina, Colombrero Cecilia, Smayevsky Jorgelina
Laboratorio de Bacteriología, Micología y Parasitología, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC).
Rev Argent Microbiol. 2011 Apr-May;43(2):81-3. doi: 10.1590/S0325-75412011000200002.
Non-O1, and non-O139 Vibrio cholerae is an infrequent cause of bacteremia. There are no reports of such bacteremia in chronic hemodialysis patients. This work describes the case of a chronic hemodialysis patient that had an episode of septicemia associated with dialysis. Blood cultures were obtained and treatment was begun with vancomycin and ceftazidime. After 6.5 hours of incubation in the Bact/Alert system there is evidence of gram-negative curved bacilli that were identified as Vibrio cholerae by conventional biochemical tests, API 20 NE and the VITEK 2 system. This microorganism was sent to the reference laboratory for evaluation of serogroup and virulence factors and was identified as belonging to the non-O1 and non-O139 serogroup. The cholera toxin, colonization factor and heat-stable toxin were not detected. The isolate was susceptible to ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, tetracycline, ceftazidime and cefotaxime by the disk diffusion method and the VITEK 2 system. The patient received intravenous ceftazidime for a 14 day- period and had a favorable outcome.
非O1群和非O139群霍乱弧菌是菌血症的罕见病因。目前尚无慢性血液透析患者发生此类菌血症的报道。本文描述了一例慢性血液透析患者发生与透析相关的败血症的病例。采集了血培养样本,并开始使用万古霉素和头孢他啶进行治疗。在Bact/Alert系统中培养6.5小时后,发现革兰氏阴性弯曲杆菌,通过常规生化试验、API 20 NE和VITEK 2系统鉴定为霍乱弧菌。该微生物被送至参考实验室评估血清群和毒力因子,鉴定为非O1群和非O139群。未检测到霍乱毒素、定植因子和耐热毒素。通过纸片扩散法和VITEK 2系统检测,该分离株对氨苄西林、复方新诺明、环丙沙星、四环素、头孢他啶和头孢噻肟敏感。患者接受了为期14天的静脉注射头孢他啶治疗,预后良好。