从诃子 Terminalia arjuna 中分离、表征和研究其乌发醇的细胞毒性。
Isolation, characterisation and cytotoxicity study of arjunolic acid from Terminalia arjuna.
机构信息
SBST, Vellore Institute of Technology University, Vellore, Tamil Nadu, India.
出版信息
Nat Prod Res. 2012;26(16):1549-52. doi: 10.1080/14786419.2011.566870. Epub 2011 Jul 7.
Arjunolic acid (AA), a triterpenoid, was isolated from the ethyl acetate and methanol extracts of Terminalia arjuna core wood. The purity of AA was analysed by its melting point, FT-IR and NMR spectroscopy analyses. In vitro cytotoxicity was assessed using Ehrlich ascites carcinoma (EAC) and Dalton's lymphoma (DAL) cell lines by incubating with different concentrations of AA. The cancer cell death percentage at 100 µg concentrations of AA ranged between 66% and 70% on the DAL and EAC cell lines, respectively. This infers that AA causes considerable membrane damage to cancer cells.
乌檀酸（AA）是一种三萜类化合物，从Terminalia arjuna 心材的乙酸乙酯和甲醇提取物中分离得到。AA 的纯度通过熔点、FT-IR 和 NMR 光谱分析进行分析。通过用不同浓度的 AA 孵育 Ehrlich 腹水癌细胞（EAC）和 Dalton 淋巴瘤（DAL）细胞系，评估了体外细胞毒性。在 DAL 和 EAC 细胞系中，AA 浓度为 100μg 时，癌细胞的死亡率分别在 66%至 70%之间。这表明 AA 对癌细胞造成了相当大的膜损伤。
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