Division of Internal Medicine, Desio General Hospital, 20033 Desio, Italy.
World J Gastroenterol. 2011 Jun 28;17(24):2941-4. doi: 10.3748/wjg.v17.i24.2941.
To investigate whether this might be related to the presence of hyperhomocysteinemia.
From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years).
Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).
The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.
研究这是否与高同型半胱氨酸血症的存在有关。
1998 年 1 月至 2008 年 12 月,我们评估了 165 例成年乳糜泻(CD)患者(138 名女性和 27 名男性,平均年龄 43 岁)中高同型半胱氨酸血症的存在情况。
32 例(19.3%)患者存在高同型半胱氨酸血症,但多数为中度升高(平均 25μg/ml;范围 15-30)。仅 1 例患者有心肌梗死病史(N5-N10-亚甲基四氢叶酸还原酶突变杂合子)。
目前,在 CD 患者中,系统评估高同型半胱氨酸血症似乎没有必要。