Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, Wentworth Way, UK.
Nat Rev Microbiol. 2011 Jul 11;9(8):604-15. doi: 10.1038/nrmicro2608.
Leishmania is a genus of protozoan parasites that are transmitted by the bite of phlebotomine sandflies and give rise to a range of diseases (collectively known as leishmaniases) that affect over 150 million people worldwide. Cellular immune mechanisms have a major role in the control of infections with all Leishmania spp. However, as discussed in this Review, recent evidence suggests that each host-pathogen combination evokes different solutions to the problems of parasite establishment, survival and persistence. Understanding the extent of this diversity will be increasingly important in ensuring the development of broadly applicable vaccines, drugs and immunotherapeutic interventions.
利什曼原虫属是一种原生动物寄生虫，通过白蛉的叮咬传播，引起一系列疾病（统称为利什曼病），影响全球超过 1.5 亿人。细胞免疫机制在控制所有利什曼原虫属的感染中起着重要作用。然而，正如本综述所讨论的，最近的证据表明，每种宿主-病原体组合都会引发不同的解决方案来解决寄生虫的建立、生存和持续存在的问题。了解这种多样性的程度将在确保广泛适用的疫苗、药物和免疫治疗干预措施的开发方面变得越来越重要。
Zotero 插件