阿曼2型糖尿病患者的血脂风险类别：国家胆固醇教育计划的影响

Lipids-risk categories in omani type 2 diabetics: impact of the national cholesterol educational program.

作者信息

Al-Bahrani Ali I, Bayoumi Riad, Al-Yahyaee Said A

机构信息

Department of Biochemistry, College of Medicine and Health Sciences Sultan Qaboos University. P.O. Box 35, Al-Khoud 123, Sultanate of Oman.

出版信息

Sultan Qaboos Univ Med J. 2006 Dec;6(2):19-25.

PMID:21748131

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3074919/

Abstract

OBJECTIVE

To evaluate the impact of the National Cholesterol Educational Program Adult Treatment Panel III (ATP III) and the Framingham Offspring Study on Omani diabetic subjects.

METHODS

221 subjects with type 2 diabetes (86 females and 135 males) and 156 non-diabetic subjects (70 females and 86 males) aged 30-70 years attending Sultan Qaboos University Hospital between 1999-2002 were recruited. Lipid profile, glucose, %HbA(1c), apoproteinA-1 and apoproteinB were measured. Low density lipoprotein was calculated using the Friedwald formula. ATP-III and Framingham Offspring Study guidelines were used to classify lipid parameters into coronary heart disease-risk categories.

RESULTS

Diabetic compared to non-diabetic subjects had significantly higher triglycerides of >1.7 mmol/L (p=0.01) and lower low density lipoprotein cholesterol of >4.2 mmol/L (p=0.012) and, in female subjects only, lower high density lipoprotein cholesterol of <1.15 mmo/L for (p<0.0001). In addition, 57% of diabetic subjects had abnormal aplipoproteinB of >1.2 g/L compared to 49% of non-diabetic subjects. Combined raised levels of triglycerides, apolipoproteinB and low levels of high density lipoprotein were found in 42% of diabetic compared to 26% of the non-diabetic subjects (p=0.05). Diabetic subjects had significantly higher (p=0.008) NCEP risk-score for coronary artery disease, however, only 34% conformed to a NCEP 10-year-risk score of >10%.

CONCLUSION

A substantial proportion of the Omani diabetic subjects were dyslipidaemic according to the ATP III guidelines. This study recommends the implementation of a lower cut-off threshold for starting lipid-modifying agents for Omani diabetics when using the 10-year Framingham Risk Scoring equation.

摘要

目的

评估美国国家胆固醇教育计划成人治疗组第三次报告（ATP III）和弗雷明汉后代研究对阿曼糖尿病患者的影响。

方法

招募了1999年至2002年间在苏丹卡布斯大学医院就诊的221名年龄在30至70岁之间的2型糖尿病患者（86名女性和135名男性）以及156名非糖尿病患者（70名女性和86名男性）。测量了血脂谱、血糖、糖化血红蛋白百分比、载脂蛋白A-1和载脂蛋白B。使用弗里德瓦尔德公式计算低密度脂蛋白。采用ATP-III和弗雷明汉后代研究指南将血脂参数分类为冠心病风险类别。

结果

与非糖尿病患者相比，糖尿病患者的甘油三酯显著更高，>1.7 mmol/L（p = 0.01），低密度脂蛋白胆固醇显著更低，>4.2 mmol/L（p = 0.012），并且仅在女性患者中，高密度脂蛋白胆固醇显著更低，<1.15 mmol/L（p < 0.0001）。此外，57%的糖尿病患者载脂蛋白B异常，>1.2 g/L，相比之下，非糖尿病患者为49%。42%的糖尿病患者甘油三酯、载脂蛋白B水平升高且高密度脂蛋白水平降低，相比之下，非糖尿病患者为26%（p = 0.05）。糖尿病患者的冠心病NCEP风险评分显著更高（p = 0.008），然而，只有34%的患者符合NCEP 10年风险评分>10%。