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使用镍钛诺支架缓解犬结肠肿瘤性梗阻。

Use of a nitinol stent to palliate a colorectal neoplastic obstruction in a dog.

作者信息

Culp William T N, Macphail Catriona M, Perry James A, Jensen Tracey D

机构信息

James L. Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80525, USA.

出版信息

J Am Vet Med Assoc. 2011 Jul 15;239(2):222-7. doi: 10.2460/javma.239.2.222.

Abstract

CASE DESCRIPTION

A 12-year-old castrated male Labrador Retriever was evaluated for clinical signs associated with colorectal obstruction.

CLINICAL FINDINGS

The dog had a 2-week history of tenesmus and hematochezia. On rectal examination, an annular colorectal mass was palpable extending orad into the pelvic canal. The original diagnosis of the colorectal mass was a mucosal adenoma. The dog was maintained on a low-residue diet and fecal softeners for a period of 13 months after initial diagnosis. At that time, medical management was no longer effective.

TREATMENT AND OUTCOME

Placement of a colonic stent was chosen to palliate the clinical signs associated with colorectal obstruction. By use of fluoroscopic and colonoscopic guidance, a nitinol stent was placed intraluminally to open the obstructed region. Placement of the stent resulted in improvement of clinical signs, although tenesmus and obstipation occurred periodically after stent placement. At 212 days after stent placement, the patient had extensive improvement in clinical signs with minimal complications; however, clinical signs became severe at 238 days after stent placement, and the dog was euthanized. Histologic evaluation of the rectal tumor from samples obtained during necropsy revealed that the tumor had undergone malignant transformation to a carcinoma in situ.

CLINICAL RELEVANCE

A stent was successfully placed in the colon and rectum to relieve obstruction associated with a tumor originally diagnosed as a benign neoplasm. Placement of colorectal stents may be an option for the palliation of colorectal obstruction secondary to neoplastic disease; however, clinical signs may persist, and continuation of medical management may be necessary.

摘要

病例描述

一只12岁去势雄性拉布拉多猎犬因出现与结肠直肠梗阻相关的临床症状而接受评估。

临床发现

该犬有2周的里急后重和便血病史。直肠检查时,可触及一个环形结肠直肠肿物,向口腔方向延伸至盆腔。结肠直肠肿物最初诊断为黏膜腺瘤。初次诊断后,该犬维持低残渣饮食并服用粪便软化剂13个月。此时,药物治疗不再有效。

治疗及结果

选择放置结肠支架来缓解与结肠直肠梗阻相关的临床症状。在荧光镜和结肠镜引导下,将一个镍钛诺支架放置在管腔内以打开梗阻区域。支架置入后临床症状有所改善,尽管置入支架后仍会周期性出现里急后重和便秘。支架置入212天后,患者临床症状有显著改善,并发症极少;然而,支架置入238天后临床症状加重,该犬实施安乐死。尸检时获取的直肠肿瘤样本的组织学评估显示,肿瘤已发生恶性转化为原位癌。

临床意义

成功在结肠和直肠置入支架以缓解与最初诊断为良性肿瘤的肿瘤相关的梗阻。结肠直肠支架置入可能是缓解肿瘤性疾病继发的结肠直肠梗阻的一种选择;然而,临床症状可能持续存在,可能需要继续进行药物治疗。

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