基于全基因组测序的群体规模 X 连锁和常染色体遗传变异分析。
Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.
机构信息
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA.
出版信息
Nat Genet. 2011 Jul 24;43(8):741-3. doi: 10.1038/ng.877.
The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.
基于 69 位女性的全基因组序列，我们发现，X 染色体和常染色体上遗传多样性的比例既受自然选择影响，也受人口统计学因素影响。尽管这一比例随着基因在种群间的遗传距离增加而增加，但欧洲人与西非人相比，无论基因距离远近，这一比例都更低。这种相对减少最合理的解释是人口统计学历史的差异，而无需援引自然选择因素。
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