National Center for Environmental Assessment, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr, MD B243-01, Research Triangle Park, NC 27711, USA.
Int J Environ Res Public Health. 2011 Jun;8(6):1865-71. doi: 10.3390/ijerph8061865. Epub 2011 Jun 1.
Few studies have explored the relationship between PM2.5 and lung cancer incidence. Although results are mixed, some studies have demonstrated a positive relationship between PM2.5 and lung cancer mortality. Using an ecologic study design, we examined the county-level associations between PM2.5 concentrations (2002-2005) and lung cancer incidence and mortality in North Carolina (2002-2006). Positive trends were observed between PM2.5 concentrations and lung cancer incidence and mortality; however, the R2 for both were <0.10. The slopes for the relationship between PM2.5 and lung cancer incidence and mortality were 1.26 (95% CI 0.31, 2.21, p-value 0.01) and 0.73 (95% CI 0.09, 1.36, p-value 0.03) per 1 μg/m3 PM2.5, respectively. These associations were slightly strengthened with the inclusion of variables representing socioeconomic status and smoking. Although variability is high, thus reflecting the importance of tobacco smoking and other etiologic agents that influence lung cancer incidence and mortality besides PM2.5, a positive trend is observed between PM2.5 and lung cancer incidence and mortality. This suggests the possibility of an association between PM2.5 concentrations and lung cancer incidence and mortality.
很少有研究探讨过 PM2.5 与肺癌发病率之间的关系。尽管结果不一，但有一些研究表明 PM2.5 与肺癌死亡率之间存在正相关关系。本研究采用生态研究设计，考察了北卡罗来纳州（2002-2006 年）县一级 PM2.5 浓度（2002-2005 年）与肺癌发病率和死亡率之间的相关性。PM2.5 浓度与肺癌发病率和死亡率之间存在正相关趋势；然而，两者的 R2 均<0.10。PM2.5 与肺癌发病率和死亡率之间的关系斜率分别为 1.26（95%置信区间 0.31，2.21，p 值 0.01）和 0.73（95%置信区间 0.09，1.36，p 值 0.03）每 μg/m3 PM2.5。分别。分别纳入代表社会经济地位和吸烟状况的变量后，这些关联略有增强。尽管变异性较高，这反映了除 PM2.5 之外影响肺癌发病率和死亡率的烟草吸烟和其他病因因素的重要性，但 PM2.5 与肺癌发病率和死亡率之间仍存在正相关趋势。这表明 PM2.5 浓度与肺癌发病率和死亡率之间可能存在关联。
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