芫荽预处理对 Wistar 白化大鼠胃黏膜损伤的保护作用。

Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats.

机构信息

College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia.

出版信息

Environ Toxicol Pharmacol. 2006 Jul;22(1):64-9. doi: 10.1016/j.etap.2005.12.002. Epub 2006 Jan 18.

DOI:10.1016/j.etap.2005.12.002

Abstract

The effect of Coriander pretreatment on gastric mucosal injuries caused by NaCl, NaOH, ethanol, indomethacin and pylorus ligation accumulated gastric acid secretions was investigated in rats. Pretreatment at oral doses of 250 and 500mg/kg, body weight was found to provide a dose-dependent protection against the (i) ulcerogenic effects of different necrotizing agents; (ii) ethanol-induced histopathological lesions; (iii) pylorus ligated accumulation of gastric acid secretions and ethanol related decrease of Nonprotein Sulfhydryl groups (NP-SH). Results obtained on the study of gastric mucus and indomethacin-induced ulcers demonstrated that the gastro protective activity of Coriander might not be mediated by gastric mucus and/or endogenous stimulation of prostaglandins. The protective effect against ethanol-induced damage of the gastric tissue might be related to the free-radical scavenging property of different antioxidant constituents (linanool, flavonoids, coumarins, catechins, terpenes and polyphenolic compounds) present in Coriander. The inhibition of ulcers might be due to the formation of a protective layer of either one or more than one of these compounds by hydrophobic interactions.

摘要

在大鼠体内研究了芫荽预处理对 NaCl、NaOH、乙醇、消炎痛和幽门结扎引起的胃酸分泌引起的胃黏膜损伤的影响。发现口服剂量为 250 和 500mg/kg 体重时，可对（i）不同坏死剂的溃疡形成作用；（ii）乙醇引起的组织病理学损伤；（iii）幽门结扎引起的胃酸分泌积累和乙醇相关的非蛋白巯基（NP-SH）减少，具有剂量依赖性保护作用。在研究胃粘液和消炎痛引起的溃疡时，芫荽的胃保护活性可能不是通过胃粘液和/或内源性刺激前列腺素介导的。芫荽中存在的不同抗氧化成分（里哪醇、类黄酮、香豆素、儿茶素、萜类化合物和多酚化合物）对乙醇引起的胃组织损伤的保护作用可能与其自由基清除特性有关。溃疡的抑制可能是由于这些化合物中的一种或多种通过疏水相互作用形成了一层保护性的物质。