低剂量 4-MBC 对成年雄性大鼠生殖轴神经内分泌调节的影响。
Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats.
机构信息
Department of Physiology, Medicine School, University of Buenos Aires (UBA), Buenos Aires, Argentina.
出版信息
Environ Toxicol Pharmacol. 2008 Sep;26(2):222-4. doi: 10.1016/j.etap.2008.04.001. Epub 2008 Apr 11.
4-Methylbenzylidene camphor (4-MBC) is an ultraviolet absorbent. The objective of this paper was to evaluate the effect of 4-MBC low-dose exposure on the neuroendocrine reproductive regulation in male rats. Wistar male adult rats were injected sc. with 4-MBC during 5 days with a dose of 2 and 10mg/kg or during 2 days with a dose of 2 and 20mg/kg. In all rats serum prolactin, LH and FSH concentration were assayed. The hypothalamus of rats injected during 2 days were also dissected to study GnRH release. Rats that received 2 and 10mg/kg of 4-MBC during 5 days showed a decrease in the LH and FSH serum concentration. In rats injected during 2 days, serum LH decreased with 2 and 20mg/kg and FSH decreased with 2mg/kg of 4-MBC. In vitro hypothalamic GnRH release also decreased in these animals. These results show that low doses of 4-MBC inhibit the reproductive axis in adult male rats.
4-甲基亚苄基樟脑（4-MBC）是一种紫外线吸收剂。本文旨在评估低剂量 4-MBC 暴露对雄性大鼠神经内分泌生殖调节的影响。雄性 Wistar 成年大鼠皮下注射 4-MBC，剂量分别为 2mg/kg 和 10mg/kg，连续 5 天；或剂量分别为 2mg/kg 和 20mg/kg，连续 2 天。所有大鼠的血清催乳素、LH 和 FSH 浓度均进行了检测。还对连续 2 天接受注射的大鼠的下丘脑进行了分析，以研究 GnRH 的释放。连续 5 天接受 2mg/kg 和 10mg/kg 4-MBC 注射的大鼠，其 LH 和 FSH 血清浓度降低。在连续 2 天接受注射的大鼠中，2mg/kg 和 20mg/kg 的 4-MBC 使血清 LH 降低，2mg/kg 的 4-MBC 使 FSH 降低。这些动物的体外下丘脑 GnRH 释放也减少。这些结果表明，低剂量的 4-MBC 可抑制成年雄性大鼠的生殖轴。
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