Verma Ramesh, Bairwa Mohan, Chawla Suraj, Prinja Shankar, Rajput Meena
Department of Community Medicine, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.
Hum Vaccin. 2011 Aug;7(8):874-7. doi: 10.4161/hv.7.8.15685. Epub 2011 Aug 1.
Varicella (chickenpox) is an acute, highly contagious viral disease with worldwide distribution. The highest prevalence occurs in the 4-10 year age group but tends to be more severe in adults. It may be fatal in neonates, immunocompromised persons, and normal adults, especially smokers. Varicella is usually a benign childhood disease, and rarely rated as an important public health problem, but this can be severe and even fatal in otherwise healthy children (< 1 out of every 10,000 cases). Chickenpox can cause pneumonia (23 out of every 10,000 cases), and is an important risk factor for developing severe invasive "strep" (group A streptococcal disease). Complications of varicella include bacterial infections (up to 5% of cases), decreased platelets, arthritis, hepatitis, pneumonia (more commonly in adults) or encephalitis (1 in 10,000 cases), which may cause a failure of muscular coordination, sometimes resulting in persistent sequelae or death. Varicella is the leading cause of vaccine-preventable death in children. Universal vaccination can cause a dramatic reduction in the incidence of varicella, associated complications, hospitalizations and fatality rates. In India, due to the high cost of the vaccine, it would be difficult to vaccinate a large percentage of the children. The government of India should consider the inclusion of varicella vaccine in the National Immunization Schedule with the help of International agencies.
水痘是一种急性、高度传染性的病毒性疾病,在全球范围内均有分布。发病率最高的年龄段为4至10岁,但在成年人中病情往往更为严重。在新生儿、免疫功能低下者以及正常成年人(尤其是吸烟者)中,水痘可能会致命。水痘通常是一种良性的儿童疾病,很少被视为重要的公共卫生问题,但在原本健康的儿童中(每10000例病例中不到1例),病情可能会很严重甚至致命。水痘可引发肺炎(每10000例病例中有23例),并且是发生严重侵袭性“链球菌”(A组链球菌病)的重要风险因素。水痘的并发症包括细菌感染(高达5%的病例)、血小板减少、关节炎、肝炎、肺炎(在成年人中更常见)或脑炎(每10000例病例中有1例),脑炎可能导致肌肉协调功能丧失,有时会造成永久性后遗症或死亡。水痘是儿童中可通过疫苗预防的死亡的主要原因。普遍接种疫苗可显著降低水痘的发病率、相关并发症、住院率和死亡率。在印度,由于疫苗成本高昂,要为很大比例的儿童接种疫苗将很困难。印度政府应考虑在国际机构的帮助下将水痘疫苗纳入国家免疫规划。