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水痘疫苗是否应纳入印度国家免疫规划?

Should the chickenpox vaccine be included in the National Immunization Schedule in India?

作者信息

Verma Ramesh, Bairwa Mohan, Chawla Suraj, Prinja Shankar, Rajput Meena

机构信息

Department of Community Medicine, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.

出版信息

Hum Vaccin. 2011 Aug;7(8):874-7. doi: 10.4161/hv.7.8.15685. Epub 2011 Aug 1.

Abstract

Varicella (chickenpox) is an acute, highly contagious viral disease with worldwide distribution. The highest prevalence occurs in the 4-10 year age group but tends to be more severe in adults. It may be fatal in neonates, immunocompromised persons, and normal adults, especially smokers. Varicella is usually a benign childhood disease, and rarely rated as an important public health problem, but this can be severe and even fatal in otherwise healthy children (< 1 out of every 10,000 cases). Chickenpox can cause pneumonia (23 out of every 10,000 cases), and is an important risk factor for developing severe invasive "strep" (group A streptococcal disease). Complications of varicella include bacterial infections (up to 5% of cases), decreased platelets, arthritis, hepatitis, pneumonia (more commonly in adults) or encephalitis (1 in 10,000 cases), which may cause a failure of muscular coordination, sometimes resulting in persistent sequelae or death. Varicella is the leading cause of vaccine-preventable death in children. Universal vaccination can cause a dramatic reduction in the incidence of varicella, associated complications, hospitalizations and fatality rates. In India, due to the high cost of the vaccine, it would be difficult to vaccinate a large percentage of the children. The government of India should consider the inclusion of varicella vaccine in the National Immunization Schedule with the help of International agencies.

摘要

水痘是一种急性、高度传染性的病毒性疾病,在全球范围内均有分布。发病率最高的年龄段为4至10岁,但在成年人中病情往往更为严重。在新生儿、免疫功能低下者以及正常成年人(尤其是吸烟者)中,水痘可能会致命。水痘通常是一种良性的儿童疾病,很少被视为重要的公共卫生问题,但在原本健康的儿童中(每10000例病例中不到1例),病情可能会很严重甚至致命。水痘可引发肺炎(每10000例病例中有23例),并且是发生严重侵袭性“链球菌”(A组链球菌病)的重要风险因素。水痘的并发症包括细菌感染(高达5%的病例)、血小板减少、关节炎、肝炎、肺炎(在成年人中更常见)或脑炎(每10000例病例中有1例),脑炎可能导致肌肉协调功能丧失,有时会造成永久性后遗症或死亡。水痘是儿童中可通过疫苗预防的死亡的主要原因。普遍接种疫苗可显著降低水痘的发病率、相关并发症、住院率和死亡率。在印度,由于疫苗成本高昂,要为很大比例的儿童接种疫苗将很困难。印度政府应考虑在国际机构的帮助下将水痘疫苗纳入国家免疫规划。

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