转移性骨病简述。
A short account of metastatic bone disease.
机构信息
Department of Periodontology and Oral Medicine, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa.
出版信息
Cancer Cell Int. 2011 Jul 27;11:24. doi: 10.1186/1475-2867-11-24.
In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical distribution of the blood vessels, by the genetic profile of the cancer cells and by the biological characteristics of the bone microenvironment that favour the growth of metastatic cells of certain cancers.Metastases to bone may have either an osteolytic or an ostoblastic phenotype. The interaction in the bone microenvironment between biological factors secreted by metastatic cells, and by osteoblasts and osteoclasts, and the osteolytic and osteoblastic factors released from the organic matrix mediate a vicious cycle characterized by metastatic growth and by ongoing progressive bone destruction. This interaction determines the phenotype of the metastatic bone disease.
在成年人中，骨骼是原发性前列腺癌、乳腺癌、肺癌和甲状腺癌转移的首选靶部位。这些癌症向骨骼转移的倾向取决于血管的解剖分布、癌细胞的基因谱以及有利于某些癌症转移细胞生长的骨骼微环境的生物学特征。骨骼转移可能具有溶骨性或成骨性表型。转移细胞分泌的生物因子与成骨细胞和破骨细胞之间，以及从有机基质中释放的溶骨性和成骨性因子在骨骼微环境中的相互作用，介导了一个以转移生长和持续进行性骨破坏为特征的恶性循环。这种相互作用决定了转移性骨病的表型。
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