Department of Infectious Diseases, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20, Ohgimachi, Kita-ku, Osaka 530-8480, Japan.
Infection. 2011 Dec;39(6):537-44. doi: 10.1007/s15010-011-0162-0. Epub 2011 Jul 29.
To determine the incidence of Herpes zoster in patients with one of 17 specific underlying diseases compared with that in patients with other underlying diseases.
We conducted a retrospective hospital-based cohort study using data from patients' electronic medical records for the period 2001-2007 of the Kitano Hospital Research Database. These analyses included 55,492 patients with one of 17 underlying diseases, which were those reported as related to the contraction of Herpes zoster. Of these, 769 patients contracted Herpes zoster. The main outcome measure was the clinical diagnosis of Herpes zoster.
The adjusted hazard ratios (95% confidence interval) for Herpes zoster in patients with the 17 diseases were compared with other patients, with the following results: brain tumor [3.84 (2.51-5.88)], lung cancer [2.28 (1.61-3.22)], breast cancer [2.41 (1.52-3.82)], esophageal cancer [4.19 (2.16-8.11)], gastric cancer [1.95 (1.39-2.72)], colorectal cancer [1.85 (1.33-2.56)], gynecologic cancer [3.45 (2.08-5.70)], malignant lymphoma [8.23 (6.53-10.38)], systemic lupus erythematosus [3.90 (2.66-5.70)], rheumatoid arthritis [2.00 (1.60-2.50)], diabetes mellitus [2.44 (2.10-2.85)], hypertension [2.04 (1.75-2.38)], renal failure [2.14 (1.65-2.79)], and disk hernia [2.18 (1.52-3.13)].
Patients with diabetes mellitus, renal failure, and malignancies have a 1.8-8.4-fold higher risk of a Herpes zoster event than patients with other diseases. Future studies should investigate alteration of the immune system in the underlying diseases and approaches for Herpes zoster prevention.
确定与其他基础疾病相比，17 种特定基础疾病之一的患者中带状疱疹的发病率。
我们使用 2001 年至 2007 年期间来自 Kitano 医院研究数据库的患者电子病历数据进行了回顾性基于医院的队列研究。这些分析包括 55492 名患有 17 种基础疾病之一的患者，这些疾病被报告为与带状疱疹的发生有关。其中，769 名患者发生带状疱疹。主要观察指标为带状疱疹的临床诊断。
将 17 种疾病患者的带状疱疹调整后危险比（95%置信区间）与其他患者进行比较，结果如下：脑瘤[3.84（2.51-5.88)]，肺癌[2.28（1.61-3.22)]，乳腺癌[2.41（1.52-3.82)]，食管癌[4.19（2.16-8.11)]，胃癌[1.95（1.39-2.72)]，结直肠癌[1.85（1.33-2.56)]，妇科癌症[3.45（2.08-5.70)]，恶性淋巴瘤[8.23（6.53-10.38)]，系统性红斑狼疮[3.90（2.66-5.70)]，类风湿关节炎[2.00（1.60-2.50)]，糖尿病[2.44（2.10-2.85)]，高血压[2.04（1.75-2.38)]，肾衰竭[2.14（1.65-2.79)]，椎间盘突出症[2.18（1.52-3.13)]。
与患有其他疾病的患者相比，患有糖尿病，肾衰竭和恶性肿瘤的患者发生带状疱疹的风险高 1.8-8.4 倍。未来的研究应探讨基础疾病中免疫系统的改变以及预防带状疱疹的方法。
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