含苦配巴油树脂、蜂胶和氢氧化钙的糊剂在大鼠皮下组织中的生物相容性评估。
Biocompatibility assessment of pastes containing Copaiba oilresin, propolis, and calcium hydroxide in the subcutaneous tissue of rats.
作者信息
Garcia Lucas, Cristiane Santos, Wilson Mestriner, Soraya Mestriner, Lopes Ruberval A, Mônica Ramos, de Freitas Osvaldo
机构信息
Department of Dental Materials and Prosthodontics, Dental School of Ribeirão Preto, University of São Paulo, Brazil.
出版信息
J Conserv Dent. 2011 Apr;14(2):108-12. doi: 10.4103/0972-0707.82601.
AIM
To assess the biocompatibility of two endodontic pastes based on calcium hydroxide and propolis, using two vehicles - non-fractionated Copaiba-oilresin (A) and volatile fraction of Copaiba-oilresin (B), in the connective tissue of rats.
MATERIALS AND METHODS
Fifteen rats had four polyethylene tubes implanted in their backs; each pair of tubes contained one of the pastes. The tube side was considered the control. After 7, 21, and 42 days, the animals were euthanized.
RESULTS
The inflammatory reaction was moderate at seven days for A and severe for B. At 21 days, it was slight for A and moderate for B; and at 42 days, it was slight for A and B. Tissue reaction ranged from slight (7 / 21 days) to no inflammation (42 days) for the control group. Statistical analysis (Kruskal-Wallis test, P < 0.01) demonstrated no significant difference between the pastes and control group (P > 0.01).
CONCLUSION
Both pastes presented satisfactory tissue reaction in the connective tissue of rats.
目的
使用两种载体——未分馏的苦配巴油树脂（A）和苦配巴油树脂的挥发性成分（B），评估两种基于氢氧化钙和蜂胶的根管糊剂在大鼠结缔组织中的生物相容性。
材料与方法
15只大鼠背部植入四根聚乙烯管；每对管子中含有一种糊剂。管子一侧作为对照。7天、21天和42天后，对动物实施安乐死。
结果
7天时，A组炎症反应为中度，B组为重度。21天时，A组为轻度，B组为中度；42天时，A组和B组均为轻度。对照组组织反应从轻度（7/21天）到无炎症（42天）。统计分析（Kruskal-Wallis检验，P<0.01）表明糊剂与对照组之间无显著差异（P>0.01）。
结论
两种糊剂在大鼠结缔组织中均呈现出令人满意的组织反应。
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