通过定量蛋白质组学揭示胰腺胰岛生物学。
Unraveling pancreatic islet biology by quantitative proteomics.
机构信息
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
出版信息
Expert Rev Proteomics. 2011 Aug;8(4):495-504. doi: 10.1586/epr.11.39.
Abstract
The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathogenesis underlying both Type 1 and Type 2 diabetes. Over the past 5 years, emerging proteomic technologies have been applied to dissect the signaling pathways that regulate islet functions and gain an understanding of the mechanisms of islet dysfunction relevant to diabetes. Herein, we briefly review some of the recent quantitative proteomic studies involving pancreatic islets geared towards gaining a better understanding of islet biology relevant to metabolic diseases.
摘要
胰岛在维持血糖稳态方面发挥着关键作用，它通过分泌胰岛素和其他几种重要的肽类激素来实现这一功能。由于胰岛功能障碍导致的胰岛素分泌受损与 1 型和 2 型糖尿病的发病机制有关。在过去的 5 年中，新兴的蛋白质组学技术已被应用于剖析调节胰岛功能的信号通路，并深入了解与糖尿病相关的胰岛功能障碍机制。在此，我们简要回顾了一些涉及胰岛的最新定量蛋白质组学研究，旨在更好地了解与代谢性疾病相关的胰岛生物学。
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