HIV 感染儿童出现 Pre-B 急性淋巴细胞白血病的治疗效果。

Successful outcome in a HIV infected child presenting with Pre-B Acute Lymphoblastic Leukemia.

机构信息

Department of Pediatric Medicine, Medical College Kolkata, 88, College Street, Kolkata 700073, West Bengal, India.

出版信息

Indian J Pediatr. 2012 Feb;79(2):267-9. doi: 10.1007/s12098-011-0533-7. Epub 2011 Aug 10.

DOI:10.1007/s12098-011-0533-7

Abstract

The present case is a 5 y old child with Pre-B Acute Lymphoblastic Leukemia (ALL), presenting with fever, pallor, purpuric spots, hepato-splenomegaly and lymphadenopathy of 20 d duration. During re-induction chemotherapy, he developed atypical skin lesions diagnosed as Varicella Zoster infection. He and his parents tested positive for anti HIV antibody. He entered complete remission and Anti-retroviral therapy (ART) along with maintenance chemotherapy has been initiated 3 mon ago. Acute leukemia is rare in HIV and probably this is the first case of Pre-B Acute Leukemia in association with perinatally transmitted HIV.

摘要

本病例为 5 岁儿童，患有前 B 急性淋巴细胞白血病（ALL），表现为发热、苍白、紫癜、肝脾肿大和淋巴结病，病程 20 天。在再诱导化疗期间，他出现了不典型的皮肤损伤，被诊断为水痘带状疱疹感染。他和他的父母 HIV 抗体检测呈阳性。他已进入完全缓解期，3 个月前开始进行抗逆转录病毒治疗（ART）和维持化疗。HIV 合并急性白血病较为罕见，这可能是首例与围产期传播 HIV 相关的前 B 急性白血病病例。