4337名医护人员接种新型H1N1流感疫苗后的自我报告不良反应。
Self-reported adverse reactions in 4337 healthcare workers immunizations against novel H1N1 influenza.
作者信息
Bias Harald, Quarcoo David, Meier-Wronski Claus, Wicker Sabine, Seybold Joachim, Nienhaus Albert, Groneberg David A, Roux Andres de
机构信息
Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
出版信息
BMC Res Notes. 2011 Aug 17;4:297. doi: 10.1186/1756-0500-4-297.
PURPOSE
The use of the 2009 H1N1 vaccine has generated much debate concerning safety issues among the general population and physicians. It was questioned if this is a safe vaccine. Therefore, we investigated the safety of an inactivated monovalent H1N1 pandemic influenza vaccine
METHODS
We focused on the H1N1 pandemic influenza vaccine Pandemrix® and applied a self reporting questionnaire in a population of healthcare workers (HCWs) and medical students at a major university hospital.
RESULTS
In total, 4337 individuals were vaccinated, consisting of 3808 HCWs and 529 medical students. The vaccination rate of the employees was higher than 40%. The majority of individuals were vaccinated in November 2009. In total, 291 of the 4337 vaccinations were reported to lead to one or more adverse reactions (6.7%). Local reactions were reported in 3.8%, myalgia and arthralgia in 3.7%, fatigue in 3.7%, headache in 3.1%.
CONCLUSIONS
Our data together with available data from several national and international institutions points to a safe pandemic influenza vaccine.
目的
2009年甲型H1N1流感疫苗的使用在普通人群和医生中引发了诸多关于安全问题的争论。人们质疑其是否为一种安全的疫苗。因此，我们调查了一种甲型H1N1流感大流行灭活单价疫苗的安全性。
方法
我们聚焦于甲型H1N1流感大流行疫苗“大流行疫苗（Pandemrix®）”，并在一家大型大学医院的医护人员和医学生群体中应用了一份自填式问卷。
结果
总共4337人接种了疫苗，其中包括3808名医护人员和529名医学生。员工的接种率高于40%。大多数人在2009年11月接种了疫苗。在4337次接种中，共有291次报告导致了一种或多种不良反应（6.7%）。报告的局部反应为3.8%，肌痛和关节痛为3.7%，疲劳为3.7%，头痛为3.1%。
结论
我们的数据以及来自几个国家和国际机构的现有数据表明，甲型H1N1流感大流行疫苗是安全的。
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