社区获得性肺炎（CAP）患者中C反应蛋白（CRP）和血清淀粉样蛋白A（SAA）的动力学，以生物半衰期表示。
Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community-acquired pneumonia (CAP), as presented with biologic half-life times.
作者信息
Takata Saori, Wada Hiroo, Tamura Masaki, Koide Takashi, Higaki Manabu, Mikura Shin-Ichiro, Yasutake Tetsuo, Hirao Susumu, Nakamura Masuo, Honda Koujiro, Nagatomo Tomoko, Tanaka Yasutaka, Sohara Erei, Watanabe Masato, Yokoyama Takuma, Saraya Takeshi, Kurai Daisuke, Ishii Haruyuki, Goto Hajime
机构信息
Department of Respiratory Medicine, Kyorin University School of Medicine , Mitaka, Tokyo , Japan.
出版信息
Biomarkers. 2011 Sep;16(6):530-535. doi: 10.3109/1354750X.2011.607189. Epub 2011 Aug 19.
Context: In management of community-acquired pneumonia (CAP), excellent biomarkers for inflammation would be helpful in our practice. Objectives: Kinetics of c-reactive protein (CRP) and serum amyloid A (SAA) was characterized, using their biologic half-life times. Materials and methods: Time course of CRP and SAA levels in the successfully treated 36 CAP patients were investigated and their half-life times were determined and compared. Results & Discussions: SAA and CRP declined in an exponential mean and the biologic half-life times of SAA levels was 34.9 ± 28.7 h, significantly shorter than that of CRP, 46.4 ± 21.7 h (p = 0.0014). Conclusion: The kinetic evidence, presented as biologic half-life times of CRP and SAA, helps us make a clinical assessment of CAP patients.
背景
在社区获得性肺炎（CAP）的管理中，优秀的炎症生物标志物将有助于我们的临床实践。目的：利用C反应蛋白（CRP）和血清淀粉样蛋白A（SAA）的生物学半衰期来表征其动力学。材料与方法：对36例成功治疗的CAP患者的CRP和SAA水平随时间的变化过程进行了研究，并测定和比较了它们的半衰期。结果与讨论：SAA和CRP呈指数下降，SAA水平的生物学半衰期为34.9±28.7小时，明显短于CRP的46.4±21.7小时（p = 0.0014）。结论：以CRP和SAA的生物学半衰期呈现的动力学证据有助于我们对CAP患者进行临床评估。
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