自然杀伤细胞分化和功能的转录控制。
Transcriptional control of natural killer cell differentiation and function.
机构信息
Medical Research Council (MRC) Centre for Transplantation, Guy's Hospital, King's College London, 5th floor Tower Wing, London SE1 9RT, UK.
出版信息
Cell Mol Life Sci. 2011 Nov;68(21):3495-503. doi: 10.1007/s00018-011-0800-9. Epub 2011 Aug 24.
Abstract
Gene expression can be modulated depending on physiological and developmental requirements. A multitude of regulatory genes, which are organized in interdependent networks, guide development and eventually generate specific phenotypes. Transcription factors (TF) are a key element in the regulatory cascade controlling cell fate and effector functions. In this review, we discuss recent data on the diversity of TF that determine natural killer (NK) cell fate and NK cell function.
摘要
基因表达可以根据生理和发育需求进行调节。大量的调节基因，它们组织在相互依存的网络中，指导着发育，并最终产生特定的表型。转录因子（TF）是调控细胞命运和效应功能的调控级联中的关键元件。在这篇综述中，我们讨论了最近关于决定自然杀伤 (NK) 细胞命运和 NK 细胞功能的 TF 多样性的数据。
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