新型肽特异性定量构效关系（QSAR）分析在具有抗血管生成活性的胶原 IV 肽中的应用。
Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity.
机构信息
Department of Biomedical Engineering, 613 Traylor Building, Johns Hopkins University, 720 Rutland Avenue, Baltimore, Maryland 21205, United States.
出版信息
J Med Chem. 2011 Oct 13;54(19):6492-500. doi: 10.1021/jm200114f. Epub 2011 Sep 13.
Abstract
Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.
摘要
血管生成是指从现有脉管系统中生长出新的血管。过度的血管生成与许多疾病有关，包括癌症。抗血管生成疗法有可能阻止癌症的进展。源自 IV 型胶原蛋白的肽是血管生成的有效抑制剂。我们希望通过基于配体的方法更好地了解胶原蛋白 IV 的结构-活性关系。我们开发了新的肽特异性 QSAR 模型，以研究肽在血管内皮细胞增殖、迁移和黏附抑制测定中的活性。我们发现，所产生的模型能够对活性进行定量准确的预测，并深入了解胶原蛋白 IV 衍生肽的结构-活性关系。
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