School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Epidemiology. 2011 Nov;22(6):793-6. doi: 10.1097/EDE.0b013e3182302e8e.
The household secondary attack proportion (SAP) is commonly used to measure the transmissibility of an infectious disease.
We analyzed the final outbreak size distributions of pandemic A(H1N1), seasonal A(H1N1), and A(H3N2) infections identified in paired sera collected from members of 117 Hong Kong households in April and in August-October 2009.
The estimated community probability of infection overall was higher for children than adults; the probability was similar for pandemic A(H1N1) and seasonal A(H3N2) influenza. The household SAP for pandemic A(H1N1) was higher in children than in adults, whereas for seasonal A(H3N2), it was similar in children and adults. The estimated SAPs were similar for seasonal A(H3N2) and pandemic A(H1N1) after excluding persons with higher baseline antibody titers from analysis.
Pandemic and seasonal influenza A viruses had similar age-specific transmissibility in a cohort of initially uninfected households, after adjustment for baseline immunity.
家庭二代发病率(SAP)常用于衡量传染病的传染性。
我们分析了在 2009 年 4 月和 8 月至 10 月期间从香港 117 户家庭成员采集的配对血清中发现的大流行性 A(H1N1)、季节性 A(H1N1)和 A(H3N2)感染的最终暴发规模分布。
总体而言,儿童感染的社区概率高于成年人;大流行性 A(H1N1)和季节性 A(H3N2)流感的感染概率相似。大流行 A(H1N1)的家庭二代发病率在儿童中高于成年人,而在季节性 A(H3N2)中,儿童和成年人的发病率相似。在排除分析中基线抗体滴度较高的人后,季节性 A(H3N2)和大流行 A(H1N1)的估计二代发病率相似。
在最初未感染的家庭队列中,大流行性和季节性甲型流感病毒的传染性具有相似的年龄特异性,这是在调整基线免疫力后的结果。