奥美拉唑对阿司匹林所致人体胃黏膜损伤的消除作用。
Abolition by omeprazole of aspirin induced gastric mucosal injury in man.
作者信息
Daneshmend T K, Stein A G, Bhaskar N K, Hawkey C J
机构信息
University Department of Therapeutics, University Hospital, Nottingham.
出版信息
Gut. 1990 May;31(5):514-7. doi: 10.1136/gut.31.5.514.
Abstract
This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to latin square. It was concluded that profound acid suppression can prevent aspirin induced gastric mucosal injury in normal subjects. This approach may prevent the development of peptic ulcers and their complications in patients taking aspirin and other non-steroidal anti-inflammatory drugs.
摘要
本研究采用拉丁方随机、双盲、交叉设计，调查奥美拉唑深度抑酸能否预防阿司匹林对人胃黏膜的损伤。研究得出结论，深度抑酸可预防正常受试者阿司匹林诱导的胃黏膜损伤。这种方法可能预防服用阿司匹林及其他非甾体抗炎药患者消化性溃疡及其并发症的发生。
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本文引用的文献
1
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Gut. 1982 Apr;23(4):340-4. doi: 10.1136/gut.23.4.340.
2
Gastrointestinal consequences of treatment with drugs in elderly patients.
J Am Geriatr Soc. 1982 Nov;30(11 Suppl):S52-7. doi: 10.1111/j.1532-5415.1982.tb01356.x.
3
Omeprazole provides protection against experimentally induced gastric mucosal lesions.
Eur J Pharmacol. 1983 Jul 15;91(1):111-4. doi: 10.1016/0014-2999(83)90370-9.
4
Omeprazole inhibition of nocturnal gastric secretion in patients with duodenal ulcer.奥美拉唑对十二指肠溃疡患者夜间胃分泌的抑制作用。
Br J Clin Pharmacol. 1984 Oct;18(4):587-90. doi: 10.1111/j.1365-2125.1984.tb02508.x.
5
Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats.苯并咪唑衍生物奥美拉唑对大鼠阿司匹林和乙醇所致胃黏膜损伤的保护作用。
Digestion. 1983;27(3):159-64. doi: 10.1159/000198946.
6
Gastric mucosal hemorrhage in dogs. Effects of acid, aspirin, and alcohol.犬胃黏膜出血。酸、阿司匹林和酒精的影响。
Gastroenterology. 1969 Mar;56(3):439-49.
7
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Br Med J. 1970 May 23;1(5707):450-2. doi: 10.1136/bmj.2.5707.450.
8
Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.非甾体抗炎药与消化性溃疡穿孔
Gut. 1985 Apr;26(4):359-63. doi: 10.1136/gut.26.4.359.
9
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Drugs. 1986 Jul;32(1):15-47. doi: 10.2165/00003495-198632010-00002.
10
Long-term omeprazole treatment in man: effects on gastric endocrine cell populations.人类长期使用奥美拉唑治疗：对胃内分泌细胞群体的影响。
Digestion. 1988;39(2):126-35. doi: 10.1159/000199615.
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