一种用于 AI-2 群体感应受体的多价探针。
A multivalent probe for AI-2 quorum-sensing receptors.
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
出版信息
J Am Chem Soc. 2011 Oct 12;133(40):15934-7. doi: 10.1021/ja207556d. Epub 2011 Sep 15.
Abstract
Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type AI-2 quorum-sensing receptors with the potential for enabling the identification of new bacterial species that utilize AI-2 as a quorum-sensing signaling molecule.
摘要
多价性是细胞受体识别的常见原则，多价激动剂和拮抗剂在理解哺乳动物细胞受体生物学方面发挥了重要作用。然而，使用类似方法研究细菌细胞受体的工作却落后了。在此，我们描述了我们开发基于树状聚合物的多价探针用于研究 AI-2 群体感应受体的努力。通过这些研究，我们发现了一种针对 Lsr 型 AI-2 群体感应受体的化学探针，它有可能识别出利用 AI-2 作为群体感应信号分子的新细菌物种。
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