西番莲的镇痛和抗炎活性
Analgesic and anti-inflammatory activities of Passiflora foetida L.
机构信息
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
出版信息
Asian Pac J Trop Med. 2011 Aug;4(8):600-3. doi: 10.1016/S1995-7645(11)60155-7.
OBJECTIVE
To investigate the analgesic and anti-inflammatory activities of ethanol extract of Passiflora foetida (P. foetida) leaves.
METHODS
Ethanol extract of P. foetida leaf was evaluated for analgesic action by acetic acid-induced writhing and hot plate method in albino mice. The anti-inflammatory property of ethanolic leaf extract was tested by carrageenan induced acute paw edema and histamine induced acute paw edema in rats.
RESULTS
The dose 200 mg/kg of P. foetida leaf extract exhibited highest significant analgesic activity [(13.50±0.43) min] at a reaction time of 20 min in hot plate method in mice. The ethanol extract of leaf dose 100 mg/kg produced a highly significant anti inflammatory effect [(1.302±0.079) mL] in rats.
CONCLUSIONS
It is very clear that P. foetida also has analgesic and anti-inflammatory activities for the pharmaceuticals.
目的
研究西番莲叶乙醇提取物的镇痛和抗炎活性。
方法
采用醋酸诱导扭体和热板法，在白化小鼠中评价西番莲叶乙醇提取物的镇痛作用。采用角叉菜胶诱导的急性爪肿胀和组胺诱导的急性爪肿胀试验，检测叶乙醇提取物的抗炎特性。
结果
西番莲叶提取物 200mg/kg 剂量在 20 分钟反应时间时在热板法中表现出最高的显著镇痛活性[(13.50±0.43)min]。叶乙醇提取物 100mg/kg 剂量在大鼠中产生了高度显著的抗炎作用[(1.302±0.079)mL]。
结论
很明显，西番莲也具有镇痛和抗炎活性，可用于制药。
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