格林-巴利综合征和慢性炎症性脱髓鞘性多发性神经病中抗 LM1 和含 LM1 神经节苷脂复合物的抗体。
Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.
机构信息
Department of Neurology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, Japan.
出版信息
J Neuroimmunol. 2011 Oct 28;239(1-2):87-90. doi: 10.1016/j.jneuroim.2011.08.016. Epub 2011 Sep 13.
LM1 is localized in human peripheral nerve myelin. Antibodies to ganglioside complexes (GSCs) have been reported in Guillain-Barré syndrome (GBS). We investigated IgG antibodies to LM1 and two GSCs (GM1 and LMI, or GD1b and LM1) in the sera of each 40 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and GBS, using ELISA. We detected anti-LM1 antibody in five with GBS and seven with CIDP; anti-GM1/LM1 antibody in three with GBS and one with CIDP; and anti-GD1b/LM1 antibody in two with CIDP. Antibodies to LM1 and LM1-containing GSCs may be among the targets for autoimmunity in GBS and CIDP.
LM1 定位于人周围神经髓鞘。在吉兰-巴雷综合征（GBS）患者中已报道抗神经节苷脂复合物（GSCs）的抗体。我们使用 ELISA 法检测了 40 例慢性炎症性脱髓鞘性多发性神经病（CIDP）和 GBS 患者血清中 LM1 及两种 GSCs（GM1 和 LMI 或 GD1b 和 LM1）的 IgG 抗体。我们在 5 例 GBS 和 7 例 CIDP 患者中检测到抗 LM1 抗体；在 3 例 GBS 和 1 例 CIDP 患者中检测到抗 GM1/LM1 抗体；在 2 例 CIDP 患者中检测到抗 GD1b/LM1 抗体。针对 LM1 和含 LM1 的 GSCs 的抗体可能是 GBS 和 CIDP 自身免疫的靶标之一。
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