Off-track takes Frizzled off the canonical path.

EMBO J 30 18, 3729–3740 (2011); published online July 19 2011 Like many other signalling pathways, the Wnt pathway is seen as part of a network that integrates extracellular information mediated by a variety of cell surface proteins to produce cell context-specific outputs. The identification of Frizzled as Wnt receptors (Bhanot et al, 1996) provided the essential link between extracellular Wnts and the intracellular components of Wnt signal transduction. Recent observations, however, indicate a rather complex interplay of this ‘core’ receptor element with an increasing number of co-receptors. In this issue of , Tolwinski and Borchers (Peradziryi et al, 2011) describe PTK7/Off-track as a novel co-receptor element that might govern specificity in cellular Wnt responses.