Biomedical Engineering Graduate Program, The University of Western Ontario, Dental Sciences Building, DSB 0015, London, ON, N6A 5C1, Canada,
J Cell Commun Signal. 2011 Dec;5(4):271-5. doi: 10.1007/s12079-011-0151-1. Epub 2011 Sep 18.
We will provide a translational view of using the recent technological advances in dental research for predicting, monitoring, and preventing the development of oral diseases by investigating the diagnostic and therapeutic role of salivary proteins. New analytical state-of-the-art technologies such as mass spectrometry and atomic force microscopy have revolutionized the field of oral biology. These novel technologies open avenues for a comprehensive characterization of the salivary proteins followed by the evaluation of the physiological functions which could make possible in a near future the development of a new series of synthetic protein for therapeutic propose able to prevent global oral diseases such as periodontal disease and dental caries, the two most prevalent oral diseases in the World.
我们将提供一个翻译视角,通过研究唾液蛋白在诊断和治疗中的作用,利用口腔研究中最近的技术进步来预测、监测和预防口腔疾病的发生。质谱和原子力显微镜等新型分析技术已经彻底改变了口腔生物学领域。这些新技术为唾液蛋白的全面特征分析开辟了道路,随后评估其生理功能,这使得在不久的将来有可能开发一系列新的合成蛋白,用于治疗目的,以预防全球口腔疾病,如牙周病和龋齿,这是世界上最普遍的两种口腔疾病。