Pérez-García Víctor M, Calvo Gabriel F, Belmonte-Beitia Juan, Diego David, Pérez-Romasanta Luis
Departamento de Matemáticas, E. T. S. I. Industriales and Instituto de Matemática Aplicada a la Ciencia y la Ingeniería, Universidad de Castilla-La Mancha, E-13071 Ciudad Real, Spain.
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Aug;84(2 Pt 1):021921. doi: 10.1103/PhysRevE.84.021921. Epub 2011 Aug 19.
We put forward a nonlinear wave model describing the fundamental dynamical features of an aggressive type of brain tumors. Our model accounts for the invasion of normal tissue by a proliferating and propagating rim of active glioma cancer cells in the tumor boundary and the subsequent formation of a necrotic core. By resorting to numerical simulations, phase space analysis, and exact solutions we prove that bright solitary tumor waves develop in such systems. Possible implications of our model as a tool to extract relevant patient specific tumor parameters in combination with standard preoperative clinical imaging are also discussed.
我们提出了一个非线性波模型,用于描述侵袭性脑肿瘤的基本动力学特征。我们的模型考虑了肿瘤边界处活跃的胶质瘤癌细胞增殖和扩散边缘对正常组织的侵袭以及随后坏死核心的形成。通过数值模拟、相空间分析和精确解,我们证明了此类系统中会出现明亮的孤立肿瘤波。我们还讨论了该模型作为一种工具,与标准术前临床成像相结合来提取相关患者特定肿瘤参数的可能意义。