[前列腺素（PG）E2在免疫调节及炎症性疾病中的作用]

[Prostaglandin(PG) E2 in regulation of immunity and inflammatory diseases].

作者信息

Xue Rui, Miao Yi-Fei, Yang Ji-Chun, Guan You-Fei

机构信息

Department of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing 100191, China.

出版信息

Sheng Li Ke Xue Jin Zhan. 2011 Jun;42(3):165-8.

PMID:21932512

Abstract

Prostaglandin(PG) E2 is an important metabolic product of arachidonic acid. PGE2 plays important roles in regulation of fever, inflammatory responses and blood pressure via four functionally antagonistic E-prostanoid (EP) receptors, which are designated as EP1, EP2, EP3 and EP4, respectively. Recently, there is increasing evidence that PGE2 also regulates the maturation of immune cells and immune response. This review aims to briefly summarize and discuss the recent findings regarding the role of PGE2 in regulation of immunity.

摘要

前列腺素（PG）E2是花生四烯酸的重要代谢产物。PGE2通过四种功能拮抗的E-前列腺素（EP）受体（分别命名为EP1、EP2、EP3和EP4）在发热、炎症反应和血压调节中发挥重要作用。最近，越来越多的证据表明PGE2还调节免疫细胞的成熟和免疫反应。本综述旨在简要总结和讨论关于PGE2在免疫调节中作用的最新研究结果。