恶性免疫海盗。
Malignant pirates of the immune system.
机构信息
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Immunol. 2011 Sep 20;12(10):933-40. doi: 10.1038/ni.2094.
DOI:10.1038/ni.2094
PMID:21934679
Abstract
At great human cost, cancer is the largest genetic experiment ever conducted. This review highlights how lymphoid malignancies have genetically perverted normal immune signaling and regulatory mechanisms for their selfish oncogenic goals of unlimited proliferation, perpetual survival and evasion of the immune response.
摘要
在巨大的人类代价下，癌症是有史以来最大的基因实验。本综述强调了淋巴恶性肿瘤如何为了其自私的致癌目标（无限增殖、永久存活和逃避免疫反应）而在遗传上扭曲了正常的免疫信号和调节机制。
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