AMP 激活的蛋白激酶：一种能量感受器，调节细胞功能的各个方面。
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.
机构信息
Division of Cell Signalling and Immunology, College of Life Science, University of Dundee, Scotland, United Kingdom.
出版信息
Genes Dev. 2011 Sep 15;25(18):1895-908. doi: 10.1101/gad.17420111.
Abstract
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP. Although best known for its effects on metabolism, AMPK has many other functions, including regulation of mitochondrial biogenesis and disposal, autophagy, cell polarity, and cell growth and proliferation. Both tumor cells and viruses establish mechanisms to down-regulate AMPK, allowing them to escape its restraining influences on growth.
摘要
腺苷酸活化蛋白激酶（AMPK）是一种能量状态传感器，可维持细胞能量平衡。它在真核生物进化的早期就出现了，其祖先的作用可能是对饥饿做出反应。最近的研究表明，激酶不仅在 AMP 增加时被激活，ADP 增加时也被激活。AMPK 虽然以其对代谢的影响而闻名，但它还有许多其他功能，包括调节线粒体生物发生和处置、自噬、细胞极性以及细胞生长和增殖。肿瘤细胞和病毒都建立了下调 AMPK 的机制，使其能够逃避 AMPK 对生长的抑制作用。
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