Division of Urology, Children's National Medical Center, Washington, DC, USA.
J Urol. 2011 Nov;186(5):2040-4. doi: 10.1016/j.juro.2011.07.023. Epub 2011 Sep 23.
Considering that there are few absolute indications for the timing and type of surgical correction of vesicoureteral reflux, we objectively measured parental choice in how the child's vesicoureteral reflux should be managed.
We prospectively identified patients 0 to 18 years old with any grade of newly diagnosed vesicoureteral reflux. All races and genders were included, and non-English speakers were excluded from analysis. Parents were shown a video presented by a professional actor that objectively described vesicoureteral reflux and the 3 treatment modalities of antibiotic prophylaxis, open ureteral reimplantation and endoscopic treatment. Then they completed a questionnaire regarding their preference for initial management, and at hypothetical followup points of 18, 36 and 54 months. Consultation followed with the pediatric urologist who was blinded to the questionnaire results.
A total of 86 girls and 15 boys (150 refluxing units) were enrolled in the study. Mean patient age was 2.6 years old. Preferences for initial treatment were antibiotic prophylaxis in 36, endoscopic surgery in 26, open surgery in 11, unsure in 26 and no response in 2. Among those initially selecting antibiotic prophylaxis, after 18 months the preference was for endoscopic treatment, but after 36 and 54 months preferences trended toward open surgery. After consultation with the pediatric urologist 68 parents chose antibiotic prophylaxis.
Our data show that antibiotic prophylaxis is preferred as the initial therapy for vesicoureteral reflux by 35.6% of parents. However, given persistent vesicoureteral reflux, preferences shifted toward surgery. With time the preference for open surgery increased and the preference for endoscopic surgery decreased.
鉴于目前对于治疗膀胱输尿管反流的时机和类型,几乎没有明确的适应证,因此我们客观地衡量了父母对患儿膀胱输尿管反流治疗方式的选择。
我们前瞻性地确定了患有任何分级新诊断膀胱输尿管反流的 0 至 18 岁患者。所有种族和性别均被纳入研究,非英语患者被排除在分析之外。我们向患儿父母展示了一段由专业演员客观描述膀胱输尿管反流和 3 种治疗方法(抗生素预防、开放输尿管再植术和内镜治疗)的视频。然后,他们完成了一份关于其对初始治疗偏好的问卷,并在 18、36 和 54 个月的假设随访点回答了问卷。之后,与小儿泌尿科医生进行了咨询,该医生对问卷结果并不知情。
共有 86 名女孩和 15 名男孩(150 个反流单位)参与了这项研究。患儿的平均年龄为 2.6 岁。初始治疗的首选为抗生素预防(36 例)、内镜手术(26 例)、开放手术(11 例)、不确定(26 例)和无反应(2 例)。在最初选择抗生素预防的患儿中,18 个月后首选内镜治疗,但 36 个月和 54 个月后,首选转为开放手术。在与小儿泌尿科医生咨询后,68 名家长选择了抗生素预防。
我们的数据显示,35.6%的家长最初选择抗生素预防作为膀胱输尿管反流的初始治疗方法。然而,由于持续存在的膀胱输尿管反流,治疗偏好转向手术。随着时间的推移,对开放手术的偏好增加,对内镜手术的偏好减少。