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[硫化氢中毒相关的致死性心肌损伤:两例报告]

[Lethal myocardial injury associated with hydrogen sulfide poisoning: report of two cases].

作者信息

Inoue Yukinori, Kumagai Ken, Tanaka Toshiharu, Yoshida Satoru, Sekiguchi Hiroshi, Kobayashi Kaori, Hirose Yasuo

机构信息

Emergency and Critical Care Medical Center, Niigata City General Hospital.

出版信息

Chudoku Kenkyu. 2011 Sep;24(3):231-5.

Abstract

We investigated two cases of hydrogen sulfide poisoning in which the patients showed lethal myocardial injury. Both patients had planned to commit suicide by inhaling hydrogen sulfide. In case 1, a 17-year-old man was confused and was brought to our hospital by ambulance. An electrocardiogram (ECG) revealed diffuse elevation of the ST segment on the second hospital day. The patient recovered and was discharged from the hospital on the 15th day. However, he died suddenly on the 18th day. In case 2, a 21-year-old man was found lying on the floor and was admitted to our hospital. ECG showed tall T waves after 5 hr. Tachycardia and tachypnea occurred after 12 hr. After 16 hr, the ECG showed a marked elevation of the ST segment, and the patient developed cardiac arrest. Even though percutaneous cardiopulmonary support was used, he died on the 4th day. It is highly probable that myocardial injury asscociated with hydrogen sulfide poisoning was not caused by systemic hypoxia but by selective myocardial toxicity. These cases demonstrate that delayed presentation of a lethal myocardial injury should be considered while treating cases of hydrogen sulfide poisoning.

摘要

我们调查了两例硫化氢中毒病例,患者均出现致命性心肌损伤。两名患者均计划通过吸入硫化氢自杀。病例1,一名17岁男性意识模糊,由救护车送至我院。入院第二天心电图(ECG)显示ST段弥漫性抬高。患者康复并于第15天出院。然而,他在第18天突然死亡。病例2,一名21岁男性被发现躺在地上,被收治入院。入院5小时后心电图显示T波高尖。12小时后出现心动过速和呼吸急促。16小时后,心电图显示ST段明显抬高,患者发生心脏骤停。尽管采用了经皮心肺支持治疗,但他在第4天死亡。与硫化氢中毒相关的心肌损伤极有可能不是由全身缺氧引起的,而是由选择性心肌毒性所致。这些病例表明,在治疗硫化氢中毒病例时,应考虑到致命性心肌损伤的延迟表现。

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