生殖细胞肿瘤的斑马鱼模型
Zebrafish models of germ cell tumor.
作者信息
Neumann Joanie C, Lillard Kate, Damoulis Vanessa, Amatruda James F
机构信息
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
出版信息
Methods Cell Biol. 2011;105:3-24. doi: 10.1016/B978-0-12-381320-6.00001-1.
Abstract
Germ cell tumors are neoplasms arising from pluripotent germ cells. In humans, these tumors occur in infants, children and young adults. The tumors display a wide range of histologic differentiation states which exhibit different clinical behaviors. Information about the molecular basis of germ cell tumors, and representative animal models of these neoplasms, are lacking. Germline development in zebrafish and humans is broadly conserved, making the fish a useful model to probe the connections between germ cell development and tumorigenesis. Here, we provide an overview of germline development and a brief review of germ cell tumor biology in humans and zebrafish. We also outline some methods for studying the zebrafish germline.
摘要
生殖细胞肿瘤是起源于多能生殖细胞的肿瘤。在人类中，这些肿瘤发生于婴儿、儿童和青年。肿瘤表现出广泛的组织学分化状态，呈现出不同的临床行为。目前缺乏关于生殖细胞肿瘤分子基础以及这些肿瘤代表性动物模型的信息。斑马鱼和人类的生殖系发育在很大程度上是保守的，这使得斑马鱼成为探究生殖细胞发育与肿瘤发生之间联系的有用模型。在此，我们概述了生殖系发育，并简要回顾了人类和斑马鱼生殖细胞肿瘤生物学。我们还概述了一些研究斑马鱼生殖系的方法。
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