巨噬细胞极化的表观遗传调控。
Epigenetic control of macrophage polarization.
机构信息
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan.
出版信息
Eur J Immunol. 2011 Sep;41(9):2490-3. doi: 10.1002/eji.201141792.
PMID:21952803
Abstract
Epigenetic control of gene expression is critical for cellular differentiation and development. Macrophage development, polarization and activation are also controlled by DNA and histone modifications. This Viewpoint summarizes the recent findings on the role of histone modifications regulating macrophage polarization toward M1 and M2 subtypes.
摘要
表观遗传控制基因表达对细胞分化和发育至关重要。巨噬细胞的发育、极化和激活也受 DNA 和组蛋白修饰的控制。本观点总结了组蛋白修饰在调节巨噬细胞向 M1 和 M2 亚型极化中的作用的最新发现。
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