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利妥昔单抗治疗非霍奇金淋巴瘤患者的疗效观察

[Efficiency therapy with rituximab in patients with non-Hodgkin's lymphomas].

作者信息

Kriachok I A, Filonenko K S, Gubareva G O, Tytorenko I B, Novosad O I, Kadnikova T V, Aleksik O M, Martynchyk A V, Kushchevyĭ É V, Pastushenko Ia V, Kutsenko L B

出版信息

Lik Sprava. 2011 Jan-Mar(1-2):117-21.

Abstract

Management of non-Hodgkin's lymphomas (NHL) has been significantly changed during last 40 years from radiotherapy to modern polychemotherapy with application of monoclonal antibodies. A ten year experience of the treatment of patients with B-cell NHL with rituximab application was accumulated in National Cancer Institute. The group of patients with NHL, who were treated in oncohematology department in the period from 2001 to 2010, was chosen for study of the efficacy of the treatment with rituximab. The immediate and distant results of the treatment were evaluated in this group of patients. The usage of the polychemotherapy with rituximab was highly efficient in the treatment of primary and relapsed patients with NHL. This group shows high rate of the immediate and distant results of treatment.

摘要

在过去40年中,非霍奇金淋巴瘤(NHL)的治疗方法发生了显著变化,从放射治疗发展到应用单克隆抗体的现代多药化疗。国家癌症研究所积累了使用利妥昔单抗治疗B细胞NHL患者的十年经验。选择2001年至2010年期间在肿瘤血液科接受治疗的NHL患者组,以研究利妥昔单抗治疗的疗效。对该组患者的近期和远期治疗结果进行了评估。利妥昔单抗联合多药化疗在治疗原发性和复发性NHL患者方面非常有效。该组显示出较高的近期和远期治疗有效率。

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