Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg, Germany.
Wiley Interdiscip Rev RNA. 2011 Mar-Apr;2(2):247-55. doi: 10.1002/wrna.49. Epub 2010 Oct 14.
Molecular biologists have traditionally focused on the very small corner of eukaryotic evolution that includes yeast and animals; even plants have been neglected. In this article, we describe the scant information that is available concerning RNA processing in the other four major eukaryotic groups, especially pathogenic protists. We focus mainly on polyadenylation and nuclear processing of stable RNAs. These processes have--where examined--been shown to be conserved, but there are many novel details. We also briefly mention other processing reactions such as splicing.
分子生物学家传统上一直专注于真核生物进化的一个非常小的角落,这个角落包括酵母和动物;甚至植物也被忽视了。在本文中,我们描述了有关其他四个主要真核生物群体,特别是致病原生动物的 RNA 加工的可用信息很少。我们主要关注多聚腺苷酸化和稳定 RNA 的核加工。这些过程在经过检验后被证明是保守的,但也有许多新的细节。我们还简要提到了其他加工反应,如剪接。