Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Inflamm Res. 2012 Jan;61(1):11-6. doi: 10.1007/s00011-011-0382-x. Epub 2011 Sep 29.
We present a retrospective analysis of previously collected blood samples to determine whether the immune response of neutrophils depends on the season i.e., short versus long days, in which blood samples were collected.
The bactericidal activity and adhesive capacity of neutrophils, the production of reactive oxygen species (ROS), and CD11b/CD18 molecule expression level were investigated. The investigated neutrophils were divided into two groups based on the time of blood collection: the winter season with short days and the summer season with long days.
We found seasonal variation in measurements of all the analyzed functional responses of neutrophils to stimuli. The strongest adhesion, as well as maximum values of ROS production, was presented by neutrophils isolated from the summer group. The highest bactericidal activity of neutrophils was also observed in blood donors from summer group.
The magnitude of the immune functional activity of neutrophils varies with the season of the year and is decreased in winter.
我们对先前收集的血液样本进行回顾性分析，以确定中性粒细胞的免疫反应是否取决于采血时的季节，即短日或长日。
研究了中性粒细胞的杀菌活性和黏附能力、活性氧（ROS）的产生以及 CD11b/CD18 分子的表达水平。根据采血时间，将研究的中性粒细胞分为两组：短日的冬季组和长日的夏季组。
我们发现所有分析的中性粒细胞对刺激的功能反应的测量值都存在季节性变化。来自夏季组的中性粒细胞表现出最强的黏附能力和最大的 ROS 产生值。在夏季组的献血者中也观察到最高的中性粒细胞杀菌活性。
中性粒细胞免疫功能活性的大小随季节而变化，冬季降低。
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