Center for Pharmaceutical Physics, Milford, New Jersey 08848, USA.
J Pharm Sci. 2012 Feb;101(2):464-84. doi: 10.1002/jps.22788. Epub 2011 Oct 11.
Papers and patents that deal with polymorphism (crystal systems for which a substance can exist in structures defined by different unit cells and where each of the forms has the same elemental composition) and solvatomorphism (systems where the crystal structures of the substance are defined by different unit cells but where these unit cells differ in their elemental composition through the inclusion of one or molecules of solvent) have been summarized in an annual review. The works cited in this review were published during 2010 and were drawn from the major physical, crystallographic, and pharmaceutical journals. The review is divided into sections that cover articles of general interest, computational and theoretical studies, preparative and isolation methods, structural characterization and properties of polymorphic and solvatomorphic systems, studies of phase transformations, effects associated with secondary processing, and US patents issued during 2010.
已在年度综述中总结了涉及多晶型(物质可以存在于由不同晶胞定义的晶体系统中,并且每种形式具有相同的元素组成)和溶剂化物多晶型(物质的晶体结构由不同的晶胞定义,但这些晶胞通过包含一个或多个溶剂分子而在元素组成上有所不同)的论文和专利。本综述中引用的文献发表于 2010 年,来自主要的物理、晶体学和制药期刊。综述分为涵盖一般兴趣文章、计算和理论研究、制备和分离方法、多晶型和溶剂化物系统的结构特征和性质、相变研究、与二次加工相关的影响以及 2010 年发布的美国专利等部分。