头颈部不明原发癌：正电子发射断层扫描（PET）与 PET/CT 的比较。
Carcinoma of unknown primary in the head and neck: comparison between positron emission tomography (PET) and PET/CT.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
出版信息
Head Neck. 2011 Nov;33(11):1569-75. doi: 10.1002/hed.21635. Epub 2010 Dec 15.
BACKGROUND
Comparison of the diagnostic validity of positron emission tomography (PET) alone with integrated PET and CT (PET/CT) in the search for occult primary tumors in patients with cancer of unknown primary (CUP) site in the head and neck.
METHODS
Thirty-nine consecutive patients with clinical CUP were investigated with PET and 38 patients with PET/CT. After initial diagnostic panendoscopy and histological confirmation of the cervical lymph node metastasis, either PET or PET/CT scanning was performed.
RESULTS
Integrated PET/CT had a significantly higher overall detection rate than dedicated PET alone (55.2% vs 30.8%; p = .039) and positive prediction rate (93.3% vs 46.1%; p = .01).
CONCLUSION
Integrated PET/CT showed to be superior to PET in the detection of the primary site of clinically occult tumors in CUP syndrome. However, a negative result should still be investigated further by means of panendoscopy with tonsillectomy and blind biopsies.
背景
比较正电子发射断层扫描（PET）单独与 PET 和 CT 整合（PET/CT）在寻找头颈部不明原发灶（CUP）癌症患者隐匿性原发肿瘤中的诊断价值。
方法
39 例临床 CUP 患者接受了 PET 和 38 例患者接受了 PET/CT 检查。在初始诊断性全内镜检查和颈部淋巴结转移的组织学确认后，进行了 PET 或 PET/CT 扫描。
结果
与单独使用 PET 相比，整合的 PET/CT 具有显著更高的整体检测率（55.2%比 30.8%；p=0.039）和阳性预测率（93.3%比 46.1%；p=0.01）。
结论
在检测 CUP 综合征中临床隐匿性肿瘤的原发部位方面，整合的 PET/CT 比 PET 更优越。然而，阴性结果仍应通过扁桃体切除术和盲目活检的全内镜检查进一步调查。
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