成纤维细胞生长因子 2：关节中的好或坏家伙？
Fibroblast growth factor 2: good or bad guy in the joint?
出版信息
Arthritis Res Ther. 2011;13(5):127. doi: 10.1186/ar3447. Epub 2011 Sep 30.
Abstract
Fibroblast growth factor 2 (FGF2) is a highly abundant growth factor found within the pericellular matrix of articular chondrocytes, but studies investigating its role have been conflicting. The paper reported by Yan and colleagues in the previous issue of Arthritis Research & Therapy proposes that differences in responses to FGF2 are most likely due to changes in the balance between the two major articular cartilage FGF receptors, FGFR1 and FGFR3. They show that the catabolic and anti-anabolic effects of FGF2 are mediated primarily through FGFR1 whereas the beneficial effects are through FGFR3. This balance is dynamic and is altered in disease and following growth factor stimulation in vitro.
摘要
成纤维细胞生长因子 2（FGF2）是一种在关节软骨细胞细胞周基质中含量丰富的生长因子，但对其作用的研究结果却存在争议。Yan 等人在之前一期的《关节炎研究与治疗》杂志上发表的论文提出，对 FGF2 反应的差异很可能是由于两种主要的关节软骨 FGF 受体 FGFR1 和 FGFR3 之间的平衡变化所致。他们表明，FGF2 的分解代谢和抗合成代谢作用主要通过 FGFR1 介导，而其有益作用则通过 FGFR3 介导。这种平衡是动态的，在疾病和体外生长因子刺激下会发生改变。
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Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.成纤维细胞生长因子受体 1 主要负责成纤维细胞生长因子 2 诱导的人关节软骨细胞的分解代谢活性。
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