巴西东北部社区高血压患者血液中氧化还原失衡的标志物。
Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil.
机构信息
Universidade Federal de Alagoas, Maceió, AL, Brazil.
出版信息
Arq Bras Cardiol. 2011 Aug;97(2):141-7.
BACKGROUND
Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension.
OBJECTIVE
To identify the redox imbalance in the blood of hypertensive.
METHODS
Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of ≥ 18.5 and ≤ 30 kg/m(2), glycemia ≤ 100 mg/dL, serum cholesterol ≤ 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol.
RESULTS
Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive correlation between systolic pressure and MDA in hypertensive and diastolic pressure and CAT in controls was obtained.
CONCLUSION
The data obtained suggest that the hypertensives were in redox imbalance, despite the possibly attenuating effect of their antihypertensive medication.
背景
最近的研究表明活性氧和氮物种参与了高血压的发生。
目的
确定高血压患者血液中的氧化还原失衡情况。
方法
在 20 名高血压患者和 21 名对照者的血液中定量检测超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽（GSH）、维生素 C、转铁蛋白、铜蓝蛋白、丙二醛（MDA）和羰基。所有个体的体重指数（BMI）≥18.5 且≤30kg/m²，血糖≤100mg/dL，血清胆固醇≤200mg/dL，不吸烟，非孕妇和哺乳期妇女，不使用别嘌醇和普罗布考，且高血压患者正在服用降压药物。所有个体均进行了为期 4 周的准备期，在此期间不饮酒、不使用维生素补充剂、地塞米松和扑热息痛。
结果
与对照组相比，高血压组的 CAT（p<0.013）、GSH（p<0.003）和 MDA（p<0.014）水平降低，而 GPx（p<0.001）和铜蓝蛋白（p<0.015）水平升高。高血压患者的收缩压与 MDA 之间以及对照组的舒张压与 CAT 之间呈正相关。
结论
尽管降压药物可能有缓解作用，但研究数据表明高血压患者处于氧化还原失衡状态。
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