Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos, Nigeria.
Arch Gynecol Obstet. 2012 Apr;285(4):951-7. doi: 10.1007/s00404-011-2105-5. Epub 2011 Oct 15.
To evaluate women with delayed childbearing after 35 years and the perinatal profile of their surviving offspring in a low-income country.
A matched case-control study of advanced maternal age (AMA) parturients above 35 years was compared to younger mothers (20-35 years) in an inner-city maternity hospital in southwest Nigeria using conditional logistic regression analysis.
A total of 513 were enlisted as cases matched with 1,539 controls. AMA was associated with marital status, occupation, parity, antenatal care and elective cesarean delivery but significantly less likely to be associated with human-immunodeficiency-virus infection and cephalopelvic disproportion. After adjusting for these maternal factors, AMA was not associated with any adverse perinatal outcomes.
Delayed childbearing after 35 years was generally not associated with adverse pregnancy outcomes in this setting and may be indicative of an appreciable awareness of the potential pregnancy risks resulting in higher uptake of obstetric services by AMA mothers.
评估在一个低收入国家中,35 岁以后生育的女性及其存活后代的围产期特征。
在尼日利亚西南部的一家市区妇产医院,采用条件逻辑回归分析,将年龄较大的(>35 岁)产妇与较年轻的产妇(20-35 岁)进行了高级别产妇年龄(AMA)的病例对照研究。
共登记了 513 例病例,并与 1539 例对照进行了匹配。AMA 与婚姻状况、职业、产次、产前保健和选择性剖宫产有关,但与人类免疫缺陷病毒感染和头盆不称的关系明显较少。在调整了这些产妇因素后,AMA 与任何不良围产期结局均无关。
在这种情况下,35 岁以后的生育延迟通常与不良妊娠结局无关,这可能表明人们对潜在妊娠风险有了相当的认识,从而导致 AMA 母亲更愿意接受产科服务。