马来酰亚胺功能化的有机钌抗肿瘤试剂及其与含巯基生物分子的结合。
Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules.
机构信息
University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria.
出版信息
Chem Commun (Camb). 2012 Feb 1;48(10):1475-7. doi: 10.1039/c1cc14713g. Epub 2011 Oct 14.
PMID:22003496
Abstract
Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.
摘要
合成了具有马来酰亚胺功能的钌(II)(芳基)抗癌化合物，使其能够与含巯基的生物分子选择性相互作用，从而强制将化合物选择性递送至肿瘤。
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