使用m序列对视网膜的时间特性进行研究。

Investigation of the temporal properties of the retina using the m-sequence.

作者信息

Hagan Richard P, Fisher Anthony C, Brown Malcolm C

机构信息

Department of Medical Physics and Clinical Engineering, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK.

出版信息

Doc Ophthalmol. 2011 Dec;123(3):179-85. doi: 10.1007/s10633-011-9295-9. Epub 2011 Oct 22.

DOI:10.1007/s10633-011-9295-9

PMID:22020345

Abstract

The mfERG provides a topographic map of function of the retina and has been used in numerous studies to identify macular, paramacular and peripheral retinal dysfunction. This study investigates the changes in response due to the presentation rate of the stimulus. Twenty subjects gave informed consent to take part in the study, which had local regional ethical committee approval. Only a single hexagon of 8° diameter was presented to reduce ambiguity when identifying the higher-order kernels (HOK). Six rates were tested using a 60-Hz CRT monitor by introducing blank (black ~0 cd/m2) filler frames (FF). The rates tested were 0FF; 1FF; 2FF; 4FF; 7FF; and 14FF. The first-order kernel had largest responses to the slower stimuli (4FF and above). HOK had largest amplitudes at faster rates with the second-order kernel peaking at 1FF. At rates with 4FF and slower, the higher-order kernels were indiscernible above the noise.

摘要

多焦视网膜电图（mfERG）提供了视网膜功能的地形图，并已在众多研究中用于识别黄斑、黄斑旁和周边视网膜功能障碍。本研究调查了由于刺激呈现速率而引起的反应变化。20名受试者知情同意参与本研究，该研究获得了当地地区伦理委员会的批准。仅呈现一个直径为8°的六边形，以减少识别高阶核（HOK）时的模糊性。通过引入空白（黑色~0 cd/m²）填充帧（FF），使用60 Hz阴极射线管显示器测试了六种速率。测试的速率为0FF；1FF；2FF；4FF；7FF；和14FF。一阶核对较慢的刺激（4FF及以上）反应最大。HOK在较快速率下具有最大振幅，二阶核在1FF时达到峰值。在4FF及更慢的速率下，高阶核在噪声之上无法辨别。