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Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids.

作者信息

Chang Wei-chen, Xiao Youli, Liu Hung-wen, Liu Pinghua

机构信息

Division of Medicinal Chemistry, College of Pharmacy and Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA.

出版信息

Angew Chem Int Ed Engl. 2011 Dec 16;50(51):12304-7. doi: 10.1002/anie.201104124. Epub 2011 Oct 24.

Abstract
摘要

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Convergent strategies in biosynthesis.
Nat Prod Rep. 2011 Jun;28(6):1054-86. doi: 10.1039/c0np00047g. Epub 2011 May 6.
2
Reductive dehydroxylation of allyl alcohols by IspH protein.
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8802-9. doi: 10.1002/anie.201000833.
3
The structure of formaldehyde-inhibited xanthine oxidase determined by 35 GHz 2H ENDOR spectroscopy.
J Am Chem Soc. 2010 Oct 13;132(40):14015-7. doi: 10.1021/ja106432h.
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Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
Acc Chem Res. 2010 Sep 21;43(9):1216-26. doi: 10.1021/ar100026v.
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Bioorganometallic mechanism of action, and inhibition, of IspH.
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. doi: 10.1073/pnas.0911087107. Epub 2010 Feb 19.
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Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1077-81. doi: 10.1073/pnas.0913045107. Epub 2009 Dec 28.
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